Figure 7

Total occurrence of negative pixels in each channel for the constrained and unconstrained analyses on Dataset A. Animal outline shown, S: Spine, T: Tumor. The constrained analysis results in no negative pixels at any point throughout the imaging time course, reflecting the consistent preservation of the non-negative constraint. The unconstrained analysis, by contrast, develops a large number of negative pixels, including numerous regions within the animal. Figure created using a combination of MATLAB and Microsoft PowerPoint.