Figure 6
From: SSC-ILD mouse model induced by osmotic minipump delivered bleomycin: effect of Nintedanib
Longitudinal Micro-CT analysis. Representative Micro-CT images of Saline, BLM and BLM + NINT lungs showing normally and poorly- aerated tissue (colored in blue and pink, respectively) at day 14 and 28 (a). Longitudinal Micro-CT quantification of poorly-aerated tissue at day 14 and 28 in Saline, BLM and BLM + NINT groups (b). Asterisks indicate a significant increase in % poorly-aerated tissue from 14 to 28 days for the BLM group (**P < 0.01, two-way ANOVA followed by Sidak’s test). The inhibitory effect of NINT treatment has been calculated as reduction of poorly-aerated tissue in the BLM + NINT group with respect to BLM at day 28 (23% inhibition, # P < 0.05; two-way ANOVA followed by Dunnett’s test). Lung compartments quantification at day 28 in Saline, BLM and BLM + NINT group (c). Asterisks indicate statistical significance of both lung compartments comparing Saline and BLM + NINT groups with BLM as control (*P < 0.05, ***P < 0.001; Chi-squared test). Data are shown as mean percentages ± S.E.M. for 8 mice per group.
