Table 3 Summary of the cytotoxicity, cell viability and hemolytic results of antibiotics and synthetic peptides (in µg/ml concentration).
Types | Agents | LC50 | Lmax (%) | IC50 | Imax (%) | HC50 | Hmax (%) |
|---|---|---|---|---|---|---|---|
Antibiotics | Amikacin | > 200 | 0.0 (0.1) | > 200 | 100.1 (7.3) | > 200 | 0.0 |
Levofloxacin | > 200 | 1.2 (0.7) | > 200 | 108.0 (2.8) | > 200 | 0 (0.0) | |
First-generation peptides | DD12 | – | – | – | – | – | – |
DD13 | – | – | – | – | – | – | |
DD32 | – | – | – | – | – | – | |
CaD1 | – | – | – | – | – | – | |
CaD2 | > 200 | 2.9 (2.2) | > 200 | 1.9 (7.3) | – | – | |
CaD3 | – | – | – | – | – | – | |
Second-generation peptides | CaD21 | – | – | > 200 | 43.9 (1.0) | – | – |
CaD22 | – | – | > 200 | 34.3 (8.2) | – | – | |
CaD23 | > 200 | 26.6 (6.5) | 54.6 (11.7) | 69.6 (7.8) | > 200 | 7.1 (3.0) |
