Table 5 Effects of drugs on the expression of iNOS, MMP-9, claudin-5, occludin and ZO-1mRNA levels in the ischemic brain tissue of MCAO rats.

From: Protective mechanism of Erigeron breviscapus injection on blood–brain barrier injury induced by cerebral ischemia in rats

Group

Dose

n

iNOS

MMP-9

Claudin-5

Occludin

ZO-1

\(\overline{x} \pm s\)

P value

\(\overline{x} \pm s\)

P value

\(\overline{x} \pm s\)

P value

\(\overline{x} \pm s\)

P value

\(\overline{x} \pm s\)

P value

Sham operation group

–

6

2.96 ± 2.53

0.140

3.05 ± 2.92

0.074

0.88 ± 0.31

0.107

3.59 ± 2.91

0.513

1.07 ± 0.61

0.007**

Model group

–

6

8.62 ± 4.92

–

10.59 ± 9.01

–

0.45 ± 0.14

–

2.98 ± 1.37

–

0.51 ± 0.21

–

Nimodipine injection group

0.5 mg/kg

6

9.12 ± 9.26

0.894

7.77 ± 9.40

0.494

0.57 ± 0.20

0.656

2.39 ± 2.04

0.528

0.43 ± 0.31

0.683

E. breviscapus injection group

5 mL/kg/day

6

4.88 ± 2.52

0.325

10.35 ± 7.46

0.953

0.57 ± 0.19

0.638

3.77 ± 1.22

0.396

0.53 ± 0.32

0.905

Scutellarin group

1.1505 mg/kg

6

7.84 ± 9.93

0.836

3.06 ± 5.09

0.074

0.43 ± 0.21

0.933

1.82 ± 1.06

0.217

0.41 ± 0.18

0.621

3,5-Dicaffeoylquinic acid group

0.2335 mg/kg

6

7.60 ± 5.45

0.787

6.53 ± 6.22

0.326

1.07 ± 0.97

0.022*

3.84 ± 1.34

0.354

0.55 ± 0.15

0.825

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