Table 2 Summary of the association between ESR1 rs9340799 polymorphism and breast cancer susceptibility.
Comparison model | No. of studies | No. of cases | No. of controls | Effect model | OR (95% CI)* | P-value |
|---|---|---|---|---|---|---|
Homozygous model | ||||||
Overall | 23 | 7296 | 12,323 | Random | 1.045 (0.887–1.231) | 0.601 |
Asian | 9 | 2211 | 2800 | Fixed | 0.845 (0.677–1.054) | 0.135 |
Caucasian | 9 | 4270 | 8716 | Random | 1.042 (0.845–1.285) | 0.701 |
Premenopause | 6 | 788 | 980 | Fixed | 0.825 (0.561–1.213) | 0.327 |
Postmenopause | 10 | 1697 | 5663 | Fixed | 0.970 (0.819–1.149) | 0.725 |
High quality | 15 | 5593 | 10,581 | Random | 1.109 (0.903–1.362) | 0.322 |
Low quality | 8 | 1703 | 1742 | Fixed | 0.921 (0.741–1.145) | 0.461 |
Heterozygous model | ||||||
Overall | 23 | 11,385 | 18,482 | Random | 0.941 (0.861–1.030) | 0.186 |
Asian | 9 | 3329 | 4206 | Random | 0.866 (0.707–1.061) | 0.164 |
Caucasian | 9 | 6861 | 12,952 | Fixed | 1.020 (0.956–1.089) | 0.546 |
Premenopause | 6 | 1294 | 1558 | Random | 0.891 (0.682–1.163) | 0.396 |
Postmenopause | 10 | 2547 | 7921 | Random | 0.908 (0.734–1.124) | 0.375 |
High quality | 15 | 8713 | 15,674 | Fixed | 0.998 (0.942–1.057) | 0.939 |
Low quality | 8 | 2672 | 2808 | Random | 0.851 (0.673–1.075) | 0.176 |
Dominant model | ||||||
Overall | 23 | 12,766 | 21,955 | Random | 0.957 (0.875–1.045) | 0.327 |
Asian | 9 | 3480 | 4428 | Random | 0.857 (0.713–1.031) | 0.102 |
Caucasian | 9 | 7931 | 16,077 | Random | 1.011 (0.905–1.130) | 0.842 |
Premenopause | 6 | 1345 | 1637 | Random | 0.812 (0.557–1.183) | 0.278 |
Postmenopause | 12 | 4000 | 11,631 | Random | 0.915 (0.785–1.066) | 0.253 |
High quality | 15 | 9907 | 18,945 | Random | 0.991 (0.897–1.095) | 0.861 |
Low quality | 8 | 2859 | 3010 | Random | 0.869 (0.714–1.058) | 0.162 |
Recessive model | ||||||
Overall | 23 | 12,766 | 21,955 | Random | 1.053 (0.908–1.222) | 0.495 |
Asian | 9 | 3480 | 4428 | Fixed | 0.858 (0.690–1.066) | 0.166 |
Caucasian | 9 | 7931 | 16,077 | Random | 1.023 (0.872–1.200) | 0.784 |
Premenopause | 6 | 1345 | 1637 | Fixed | 0.812 (0.557–1.183) | 0.278 |
Postmenopause | 10 | 2917 | 10,265 | Fixed | 1.003 (0.868–1.158) | 0.967 |
High quality | 15 | 9907 | 18,945 | Random | 1.091 (0.916–1.299) | 0.330 |
Low quality | 8 | 2859 | 3010 | Fixed | 0.954 (0.773–1.179) | 0.664 |
Allele model | ||||||
Overall | 23 | 12,766 | 21,955 | Random | 0.987 (0.919–1.059) | 0.709 |
Asian | 9 | 3480 | 4428 | Random | 0.888 (0.782–1.009) | 0.068 |
Caucasian | 9 | 7931 | 16,077 | Random | 1.015 (0.924–1.114) | 0.760 |
Premenopause | 6 | 1345 | 1637 | Fixed | 0.952 (0.845–1.074) | 0.426 |
Postmenopause | 10 | 2917 | 10,265 | Fixed | 0.972 (0.904–1.046) | 0.451 |
High quality | 15 | 9907 | 18,945 | Random | 1.018 (0.933–1.111) | 0.687 |
Low quality | 8 | 2859 | 3010 | Fixed | 0.949 (0.875–1.030) | 0.212 |
