Table 5 Highly interacting and hydrogen bond generating amino acid residues of CRY1 with molecules.
From: Structure-based design and classifications of small molecules regulating the circadian rhythm period
Molecules | Interacting amino acids | Hydrogen-bond forming amino acids |
|---|---|---|
A7 | Leu-255, Gln-289, Asp-389, Ile-392, Ser-396, Trp-399 | Arg-293, His-359 |
M17 | Leu-255, Gln-289, Leu290, Trp292, Arg-293, Ile-392 | Arg-293 |
M35 | Leu-255, Gln-289, Trp-292, Arg-293, Ile-392, Trp-399 | Arg-293, His-359 |
M47 | Leu-255, Gln-289, Leu-290, Arg-293, His-355, His-359 | Arg-293, His-359 |
M49 | Leu-255, Gln-289, Arg-293, His-355, Ile-392, Trp-399 | Arg-293, Gln-289, His-355 |
M54 | Leu-255, Gln-289, Trp-290, Arg-293, Ile-392, Trp-399 | His-359, Ser-395 |
M78 | Leu-255, Gln-289, Trp-292, Arg-293, Ile-392, Trp-399 | Ser-396 |
