Figure 1
From: Multiscale computational modeling of cancer growth using features derived from microCT images
(A) Representative multiscale computational model results of tumor growth and microvessel development for a simulation period of 30 d. Model initialization was performed using spatial input data from the in vivo contrast-enhanced microscale computed tomography (microCT) image of the segmented tumor microvascular network (red). New simulated microvascular segments (green) tend to grow toward the tumor location in response to a vascular endothelial growth factor (VEGF) gradient produced by hypoxic cancer cells. (B) Simulated changes in tumor size follow the classic exponential growth model. Initially, (C) existing vessel length is insufficient to supply the necessary nutrients to hypovascular areas before new microvascular growth, (D) leading to increased intratumoral vessel density, which is an indicator of tumor angiogenesis.
