Figure 2
Magnetic resonance spectra and neurotransmitter levels. (A) MR spectra of the right primary motor cortex (M1) acquired in one subject (STEAM, TR/TE = 5000/5.68 ms; mixing time = 40 ms; vector size = 2048; bandwidth = 4000 Hz/Px; average = 64), as well as LCModel spectra fit for Glutamate and GABA are shown. The 2 × 2 × 2 cm3 volume of interest (black square) is centered over the hand knob area of M1 identified using fMRI during a finger opposition task (red) and is superimposed on the T1w MPRAGE image. Cho, choline; Cr, creatine; PCr, phosphocreatine; Gln, glutamine; Glutamate, Ins, myo-inositol; NAA, N-acetylaspartate; NAAG, N-acetylaspartylglutamate; Asp, aspartateaspartate; Tau, taurine. (B) Task-related changes in GABA and Glutamate (Glu) levels. The left and middle columns indicate the concentrations of GABA and Glu within the right M1 during the pre-task, during-task, and post-task of Learning Group (Top) and those of Control Group (Bottom). The right column show the association between GABA and Glu changes post motor sequence learning task of the Learning Group (Top) and Control Groups (Bottom).
