Figure 6
Region of interest (ROI)-based analysis of functional connectivity between the right primary motor cortex (M1) and sensorimotor network (SMN), and fronto-parietal network (FPN). (Top Left) M1 seed ROI depicted by the linear increments in preparation-related activity of the Learning Group. The level of statistical significance is set at p < 0.05, family-wise error corrected for multiple comparisons at the voxel-level. (Top Right) ROI overlap of SMN (blue) and FPN (green) with the learning-related network, depicted by the linear increments in preparation-related activity using task functional magnetic resonance imaging (red). SMN and FPN are defined based on the CONN toolbox. (Middle) Relationships between Glu/GABA changes within the right M1 and M1 seed-based resting-state functional connectivity changes in the SMN (Middle left) and FPN (Middle right) after motor sequence learning of the Learning and Control Groups (Bottom). M1 seed-based resting-state functional connectivity changes were calculated using the sum of changes in the connectivity values between the pre- and post-task periods in the networks.
