Table 1 125I-insulin regional vascular binding in males.

From: Effects of apolipoprotein E isoform, sex, and diet on insulin BBB pharmacokinetics in mice

MALES

E3 LFD

E3 HFD

E4 LFD

E4 HFD

p

Region

Vi

SEM

Vi

SEM

Vi

SEM

Vi

SEM

Olfactory bulb

5.9

3.3

0.4

2.0

4.8

3.5

4.8

2.4

 

Frontal cortex*

4.0

1.1

2.5

1.4

3.8

1.5

3.9

0.7

0.008

Striatum

3.6

2.5

2.5

1.6

4.4

3.2

4.2

3.2

 

Hypothalamus

3.8

3.5

1.9

3.3

8.0

2.8

3.2

3.1

 

Hippocampus*

7.1

3.2

1.5

3.6

4.7

4.4

3.0

1.6

0.026

Thalamus

6.7

2.3

2.3

1.1

4.1

3.8

6.2

1.4

 

Parietal cortex*

5.8

1.5

3.8

1.3

3.4

2.6

2.7

1.1

0.006

Occipital cortex*

5.0

2.0

0.2

1.4

4.1

2.1

3.3

1.4

0.017

Cerebellum*

7.5

2.5

1.0

1.5

8.1

3.0

6.3

1.3

0.0003

Midbrain*

4.5

1.3

− 1.1

1.9

3.7

1.7

3.5

0.5

0.023

Pons/medulla

4.5

3.5

1.7

1.2

3.6

3.8

3.4

1.4

 
  1. Bold cells represent regions where *p < 0.05 between groups. Vi: reversible vascular binding, SEM: ± standard error mean, p: significance between groups.
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