Table 2 Baseline characteristics of ACLF, CLD and Healthy controls used in qRT-PCR validation.

From: Inflammatory signature in acute-on-chronic liver failure includes increased expression of granulocyte genes ELANE, MPO and CD177

Variables

ACLF (n = 30)

CLD (n = 15)

Healthy control (n = 15)

p-value

Age (years)

46 ± 13

39 ± 10

35 ± 9

0.3706

Gender (No. of males)

21

10

8

0.479

Hemoglobin (gm/dL)

8.40 (6.90–10.03)

11.1 (9.9–13.8)

n.a

 < 0.0001

TLC (count/µl)

12,831 ± 7455

4480 ± 3693

n.a

0.0043

Platelet × 1000/µL

76.50 (37.25–125.0)

n.a

n.a

n.a

INR

2.10 (1.80–3.62)

1.2 (1.0–2.41)

n.a

0.008

Creatinine (mg)

1.4 (1.0–2.22)

0.90 (0.7–1.0)

n.a

0.001

Sodium (mEq/L)

140 ± 9.6

n.a

n.a

n.a

Bilirubin (mg)

12.10 (4.27–24.28)

1.2 (0.4–2.0)

n.a

 < 0.0001

AST(IU/L)

88.0 (64.25–146.8)

44.0 (28.0–67.25)

n.a

0.001

ALT (IU/L)

39.0 (27.75–59)

36.0 (22.0–48.0)

n.a

0.0.32

SAP (IU/L)

233.5 (189.5–293.0)

305.0 (240.0–529.5)

n.a

0.04

Albumin (gm)

2.78 ± 0.59

n.a

n.a

n.a

Neutrophil to lymphocyte ratio (NLR)

8.2(4.0–14.1)

1.90 (1.3–8.90)

n.a

 < 0.0001

  1. Acute on chronic liver failure (ACLF) n = 30, Chronic liver disease (CLD) n = 15, Healthy controls (HC) n = 15. Parameters which pass the Pearson Normality test are represented by Mean ± SD, and the rest are represented as Median (25th Quartile -75th Quartile). For samples with normal distribution, students T test was performed, and for samples with skewed distribution. Mann whitney test was performed.
  2. Note: NLR has been calculated for 28 out of 30 ACLF patients, and 13 out of 15 CLD patients.
  3. HB = Hemoglobin, TLC = Total leukocyte count, PT = Prothrombin time, INR = International normalized ratio, AST = Aspartate aminotransferase, ALT = Alanine aminotransferase, SAP = Serum Alkaline phosphatase.
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