Figure 6 | Scientific Reports

Figure 6

From: PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression

Figure 6

Model summarizing the relationship between PIGN expression aberration, SAC regulation, and leukemia progression. PIGN depletion results in SAC dysregulation and ultimately results in segregation errors and aneuploidy which contribute to leukemia progression. PIGN plays a vital role in the regulation of mitotic integrity to maintain chromosomal stability.

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