Figure 3 | Scientific Reports

Figure 3

From: Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery

Figure 3

Cholinergic vasodilator responses of the ophthalmic artery to inhibition of the production of CYP-derived arachidonic acid lipid mediators. (a) Non-selective phospholipase inhibitor, quinacrine partially attenuated the vasodilator responses to ACh. The inhibition of CYP epoxygenase with 10 µmol/L of (b) MSPPOH and (c) sulfaphenazole resulted in marked blunting of the dilatory responses. However, the inhibition of CYP ω-hydroxylase with (d) HET0016 (1 µmol/L) conferred negligible inhibitory effects on ACh-induced vasodilation. Values are expressed as mean ± standard error of the mean (s.e.m), n = 6 per group. Absence of error bar indicates that the s.e.m was less than the size of the symbol. *P < 0.05 vs. L-NAME + indomethacin; ****P < 0.0001, n.s. non-significant, vs. L-NAME + indomethacin + baicalein.

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