Figure 4 | Scientific Reports

Figure 4

From: Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery

Figure 4

Changes in the vasoreactivity of ophthalmic artery in response to the inhibition of EET catalysis and direct antagonism of EETs. The administration of 100 nmol/L of sEH inhibitors comprising (a) AUDA and (b) TPPU resulted in significant reduction of vasodilation, whereas the selective inhibition of EETs with (c) 14, 15-EEZE (10 µmol/L) showed a noticeable increment in the pre-constricted vascular diameter albeit not statistically significant. Values are expressed as mean ± s.e.m, n = 6 per group. Absence of error bar indicates that the s.e.m was less than the size of the symbol. *P < 0.05; ***P < 0.001, n.s. non-significant, vs. L-NAME + indomethacin + baicalein.

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