Figure 6 | Scientific Reports

Figure 6

From: Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery

Figure 6

Schematic overview of the hypothesized mechanisms underlying CYP-mediated vasoconstriction on the murine ophthalmic artery. CYP localised in the vascular smooth muscle cell (VSMC) mediates the synthesis of EETs, which stimulate the activation and translocation of transient receptor potential (TRP) channel, resulting in elevated intracellular Ca2+ concentration [Ca2+]i. This then leads to membrane depolarization and activation of voltage-gated calcium channels and vasoconstriction. PLA2, Phospholipase A2; AA, arachidonic acid; TRP, transient receptor potential channel; VDCC, voltage-dependent calcium channel(s); Question mark represents the unknown TRP channel.

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