Figure 1
Serum protein profiling by DIA-MS analysis of severe COVID-19 patients with adverse or favorable prognosis. (A) Study design for identification of potential biomarker candidates. Serum protein profiling was performed by DIA-MS analysis discovery study comprising five patients each with adverse and favorable prognosis. (B) A PCA score plot for proteins in the two groups was generated using Perseus. Severe COVID-19 patients with adverse or favorable prognosis are represented by red and blue, respectively. (C) Volcano plot representing the difference in serum expression levels of 495 proteins between the two groups. Red or blue dots indicate proteins with increased or decreased serum expression levels, respectively, in patients with adverse prognosis compared to those with favorable prognosis (p < 0.01, difference [adverse/favorable] > 2) (listed in Table 1). (D) Heatmap visualization of the 27 differentially expressed proteins between severe COVID-19 patients with adverse or favorable prognosis. Darker colors indicate a greater increased or decreased effect (red for increased and blue for decreased). Gene names are shown on the left.
