Figure 1 | Scientific Reports

Figure 1

From: Time-lapse monitoring of fertilized human oocytes focused on the incidence of 0PN embryos in conventional in vitro fertilization cycles

Figure 1The alternative text for this image may have been generated using AI.

Time from insemination to first cleavage, the proportion of PN faded embryo, and correlation between t2 and time of PN fading. (A) The time from the initiation of insemination to first cleavage (t2) in 0PN- and 2PN-derived embryos in the fixed-point observation group and 2PN-derived embryos in the TLM group (n = 12, 82, and 339, respectively). The 0PN-derived embryos had a significantly earlier t2 than the 2PN-derived embryos in both groups. Data were analyzed using the Wilcoxon test. **P < 0.0001. (B) The proportion of PN faded embryo after 18–22 h from insemination. In the TLM group, the proportions of PN faded embryo at 18–22 h from insemination were 0.20% (1/514, 2PN = 1), 2.5% (12/154, 2PN = 12, 3PN = 1), 7.59% (39/514, 2PN = 36, 1PN = 2, 3PN = 1), 15.6% (80/514, 2PN = 72, 1PN = 3, 3PN = 4, 4PN or more = 1), and 25.5% (131/514, 2PN = 115, 1PN = 4, 3PN = 9, 4PN or more = 3), respectively. In the fixed-point observation group, proportions of PN faded embryos were 3.6% (5/139, 2PN = 5) at 21 h after insemination and 10.8% (15/139, 2PN = 15) at 18–22 h post-insemination. (C) The correlation between t2 and time of PN fading (tPNf) of 2PN-derived embryos in the TLM group (n = 331). There was a significant positive correlation observed between t2 and tPNf. PN pronuclei; TLM time-lapse monitoring.

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