Figure 3
Oral CuATSM treatment delays weight loss and extends survival in SOD1G93A mice (n = 13/treatment). SOD1G93A mice were administered CuATSM or vehicle and (a) body weight recorded three times a week. (b) The mean age to reach peak body weight (+ SEM) and (c) maximum mean body weight (+ SEM) were measured. (d) A Kaplan–Meier curve of CuATSM- and vehicle-treated SOD1G93A mice and (e) median survival (+ SEM) (n = 13/treatment). Repeated measures ANOVA were used to compare body weight change followed by post-hoc with Fisher’s least significance difference corrections. Independent t test were used to compare maximum body weight, age at maximum body weight and median survival between CuATSM- and vehicle-treated mice SOD1G93A mice. *p < 0.05 compared to age- and sex-matched vehicle treated mice.
