Table 3 Concordance analysis per chromosome pair.

From: High concordance in preimplantation genetic testing for aneuploidy between automatic identification via Ion S5 and manual identification via Miseq

 

Ion S5

Miseq

Total chromosome pairs

2392

2392

Chromosomes with conclusive result a

2277

2277

Chromosomes with inconclusive result

115

115

Chromosomes with aneuploid calling b

107

95

Chromosome category

 Diploid

2170 (95.3%)

2182 (95.8%)

 Low-rate mosaic (20–50%)

27 (1.2%)

22 (1.0%)

 High-rate mosaic (50–80%)

15 (0.7%)

15 (0.7%)

 Aneuploid

65 (2.8%)

58 (2.5%)

Overall concordant chromosome pairs c

2265

 

Overall non-concordant chromosome pairs d

12

 

Concordance rate per chromosome pair

99.47%

 
  1. aIt excludes embryos with chaotic mosaicism, in which the individual chromosomes affected could not be distinguished.
  2. bIt includes individual chromosome pairs with mosaicism or aneuploidy.
  3. cChromosome pairs identified as diploid or mosaic/aneuploid on the both two NGS systems. Mosaic/aneuploid chromosome pairs with different aneuploid percentages on each system are also included.
  4. dChromosome pairs identified as diploid on the only one system, and as mosaic/aneuploid on the other system.
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