Figure 4

Water molecules displacement in APO-EcAII (green, 6YZI) and EcAII-ASP (pink, 1NNS) active site. (a) Coordinated waters in APO-EcAII. (b) Coordinated waters in EcAII-ASP. (c) Water molecules found in APO-EcAII (green) and EcAII-ASP (red) superposition. Black arrows indicate waters conserved in the two structures. (d) Superposition of (a) and (b). (e) Residues involved in contacts with water molecules conserved in APO and EcAII-ASP active site.