Figure 2
From: Adipose expression of CREB3L3 modulates body weight during obesity
Fat-specific ablation of CREB3L3 enhances diet-induced obesity and insulin resistance. (a) Weekly body weight measurements of CREB3L3 floxed controls (ctrl) and fat-specific knockout (fKO) mice during 10 wks of high-fat diet feeding (n = 4–6 mice per group). (b) Tissue weight measurements for control and fKO mice after high-fat feeding (n = 4–6 mice per group). (c) Body composition following high-fat feeding measured by NMR (n = 6–10 mice per group). (d, e) Intraperitoneal (d) insulin and (e) glucose tolerance tests performed with high fat-fed control and fKO mice (n = 6–8 mice per group). (f) Fed and fasted plasma insulin concentrations measured with ELISA (n = 12–17 mice per fed group; 8 mice per fasted group). Data presented as mean ± SEM with sample sizes listed above. The difference in means was analyzed using Student’s t-test where *P < 0.05 and **P < 0.01.
