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Figure 1

From: Sarcopenia-derived exosomal micro-RNA 16-5p disturbs cardio-repair via a pro-apoptotic mechanism in myocardial infarction in mice

Figure 1

Skeletal muscle atrophy due to sustained tail-suspension after I/R. (a) Experimental sarcopenia was induced via using the modified Morey’s tail-suspension (TS) model. Analysis of the weight of the gastrocnemius (b) and of the limb strength (c) in TS (+) (n = 8) and TS (−) (n = 9) mice. Left bar; TS (−), Right bar; TS (+). (d) An evident reduction of the myofiber cross-sectional area (CSA) was observed in TS (+) mice. Histological findings of the gastrocnemius of TS (+) (lower) and TS (−) (upper) mice. Left side; cross-section of the gastrocnemius; scale bar = 500 μm. Right side; enlarged figure of the myofibers; scale bar = 100 μm. (e) Automatic detection of the CSA of myofibers using the BZ-X Analyzer software (Keyence. Co.). Scale bar = 100 μm. (f) Analysis of the CSA of the myofibers. Left bar; TS (−), Right bar; TS (+).

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