Figure 2 | Scientific Reports

Figure 2

From: Sarcopenia-derived exosomal micro-RNA 16-5p disturbs cardio-repair via a pro-apoptotic mechanism in myocardial infarction in mice

Figure 2

Experimental sarcopenia impairs cardiac after I/R. (a) Absolute changes in the LVEF on days 1, 8 in TS (+) (n = 15) and TS (−) (n = 13; 2 mouse early death), days 29 in TS (+) (n = 5) and TS (−) (n = 4), ΔLVEF (b, Day 8–Day 1, c Day 29—Day 1) in the 2 groups of mice. Left bar; TS (−), Right bar; TS (+). *p < 0.05, **p < 0.001 vs. TS (+). (d) Representative images of cardiac tissue sections (short axis view; day 28 post-MI) stained with Masson’s Trichrome. The fibrotic areas are stained blue. Left side; TS (−). Right side; TS (+). Scale bar = 0.5 mm. (e) Quantitative analysis of the percentage of the fibrotic area as a function of the total LV area (n = 6 per group). Left bar; TS (−), Right bar; TS (+).

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