Figure 3 | Scientific Reports

Figure 3

From: Sarcopenia-derived exosomal micro-RNA 16-5p disturbs cardio-repair via a pro-apoptotic mechanism in myocardial infarction in mice

Figure 3

Specific exosomal-micro-RNAs in sarcopenic mice after I/R. (a) Comprehensive cluster analysis of miRNAs expression in the exosomes from I/R mice (both groups) showing the 68 differentially expressed miRNAs (fold change > 2.0). Green; down regulated miRNAs. Red; upregulated miRNAs. Left 3 lines; TS (−) mice. Right 3 lines; TS (+) mice. (b) Volcano plot analysis of 944 miRNAs. The horizontal lines show the p-values with respect to the differential expression analysis in the two groups. Two candidate miRNAs (upregulated) with a high differential expression ratio were plotted over the horizontal line. (c) Quantitative (q) RT-PCR analysis of the expression of miR-16-5p, miR-144-3p, and miR-24-3p in the two groups of I/R mice [I/R (+) TS (+); n = 9, I/R (+) TS (−); n = 6, I/R (−) TS (−); n = 3]. Left bar; I/R (−) TS (−). Center bar; I/R (+) TS (−). Right bar; I/R (+) TS (+).

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