Figure 2
From: Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis
Intercellular communications in the sinusoidal signaling niche. (a) Heatmap showing the number of potential ligand-receptor pairs between any two liver cell types predicted by CellphoneDB. (b) Dotplot displaying putative ligand-receptor interactions between aHSCs and other cell types. Dot size represents statistical significance of the indicated interactions. Dot color indicates the average expression level (log2-transformed) of the receptor from aHSCs and the ligand from another cell type. (c–f) Gene expression of ITGAV, LAMC1, TNFRSF11B, and VWF at progressive disease stages. The RNA-seq data were downloaded and reanalyzed from Gerhard et al. (2018). Mann–Whitney U tests (two-sided) were performed for statistical comparisons. logCPM, log-transformed counts per million.
