Figure 4
From: Spatiotemporal development of coexisting wave domains of Rho activity in the cell cortex
Two stages of pattern development and characteristics of the regimes in the low-activity stage. (A,B) The amplitude of the activator pattern, \(\underset{{x},{y}}{\text{max}}A-\underset{{x},{y}}{\text{min}}A\), during the low- and high-activity stages for the quasi-static low-activity regime (\({k}_{0}=0.2\), \({s}_{2}=0.8\)) and the oscillatory low-activity regime (\({k}_{0}=0.2\), \({s}_{2}=1.1\)), respectively. (C,D) The same plots as in (A), (B), but in the log scale. (E,F) A series of snapshots of the system behavior from the same parameters as in (A,C) and (B,D), respectively (see also Supplementary Videos S4–S6). The concentrations were scaled as \(\left[C-\text{min}C\right]/\left[\text{max}C-\text{min}C\right]\) both for the inhibitor (red channel) and the activator (green channel) before the channels were merged together. (G,H) (Left panels) Snapshots of the system in the quasi-static (\({k}_{0}=0.2\), \({s}_{2}=0.8\)) and oscillatory (\({k}_{0}=0.2\), \({s}_{2}=1.1\)) regimes of the low-activity stage; top and bottom panels respectively. (Central panels) Kymographs of the system dynamics along the vertical lines shown in the left panels. For comparison of patterns with different amplitude, the concentration values were scaled to zero mean and standard deviation equal to one (mean value was subtracted from each pixel and then divided by standard deviation). (Right panels) Temporal autocorrelation plots, showing the correlation coefficient as a function of the time lag (see “Methods”). (I) Classification of the parameter space with white and red colors indicating the quasi-static and oscillatory regimes, respectively. (J) Colormap showing the duration of the low-activity stage (in s).
