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Figure 2

From: Iron homeostasis in the absence of ferricrocin and its consequences in fungal development and insect virulence in Beauveria bassiana

Figure 2

Beauveria bassiana BCC 2660 ferS and three SidC-like nonribosomal peptide synthetases (monomodular SidC1, SidC2 and SidC3) and sequence relationships with other ferricrocin and ferrichrome synthetases. (A) Domain organization of adenylation domain (A), thiolation domain (T), and condensation domain. The predicted amino acid substrate for each A domain is indicated. Abbreviations for these amino acids are as follow: HO, N5-acetyl-N5-hydroxyornithines; G, glycine; and Ser, serine. (B) Phylogenetic tree of the A domains of ferricrocin and ferrichrome synthetases was constructed using the neighbor-joining method. Bootstrap supports are percentages of 1000 replicates, and values of ≥ 80% are shown. B. bassiana A domains of FerS and three SidC-like NRPSs are highlighted in rectangles. The proteins used in this phylogenetic analysis are given in the Methods. Fungal ferrichrome synthetases are divided into two lineages, NPS1/SidC and NPS2. Accession numbers of all the NRPSs used in this phylogeny are provided in Supplemental File S5.

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