Figure 1 | Scientific Reports

Figure 1

From: Controlling for background genetic effects using polygenic scores improves the power of genome-wide association studies

Figure 1

The proportion of causal variants recovered in 100 simulations. The boxplot shows the median (center line), upper and lower quartiles (hinges) and the maximum and minimum values not more than 1.5 times the interquartile range from the corresponding hinge (whiskers). The simulations consisted of 100,000 individuals and a continuous trait, with narrow-sense heritability of 0.5 and 1000 causal variants. BOLT-LMM-165 denotes BOLT-LMM with a GRM derived from 165,684 variants resulting from strict LD-pruning. BOLT-LMM-664 refers to the use of BOLT-LMM with a GRM derived from all 664,393 variants in the simulations. Methods that include PGS in the name involved the use of a LOCO PGS fixed effect, derived either from pruning and thresholding (methods ending in PT) or using LDpred2.

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