Table 2 Tissue overview, categorized by fluorescence visibility and WHO grade (I, II = LGG; III, IV = HGG).

From: Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery

Fluorescence visibility

# of Samples

Mean [PpIX620]

Mean [PpIX634]

Mean ratio [PpIX620]/ [PpIX634]

Proliferation index (Ki-67)

None

612

0.0542 ± 0.0023

0.2517 ± 0.0145

0.4004 ± 0.0490

17.436 ± 0.591

Weak

214

0.1556 ± 0.0129

2.2270 ± 0.1386

0.1185 ± 0.0107

29.327 ± 1.191

Strong

1746

0.2262 ± 0.0127

10.5886 ± 0.2699

0.0366 ± 0.0016

24.118 ± 0.289

p-value

–

 < 0.001

 < 0.001

 < 0.001

 < 0.001

WHO grade

I

40

0.0018 ± 0.0006

0.0153 ± 0.00019

0.0799 ± 0.0256

1.00 ± 0.000

II

436

0.1281 ± 0.01456

1.4830 ± 0.1320

0.4303 ± 0.0669

6.00 ± 0.146

III

490

0.1000 ± 0.0085

3.8423 ± 0.2220

0.1145 ± 0.0108

18.514 ± 0.386

IV

1606

0.2227 ± 0.0132

10.3627 ± 0.2952

0.0487 ± 0.0022

28.871 ± 0.304

p-value

 

 < 0.001

 < 0.001

0.007

 < 0.001

  1. The given uncertainty is the standard error of the mean. Units are a.u.
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