Figure 1
CFU enumeration of M. tuberculosis H37Rv in latent tuberculosis after diabetes development. Log10 CFU counts in lungs and spleen of mice from Group-I, Group-II and Group-III at different time points of streptozotocin treatment. (A) Lungs after 9 weeks (B) Spleen after 9 weeks (C) Lungs after 13 weeks (D) Spleen after 13 weeks of streptozotocin treatment. The data were represented as Mean ± SE of 5 animals in each group and the statistical significance was determined by Mann–Whitney test. **p ≤ 0.01, *p ≤ 0.05. Group-I: latent tuberculosis only, Group-II: latent tuberculosis with diabetes and Group-III: latent tuberculosis with immunosuppression. Animal model was developed only once but CFU enumeration was done in triplicates from each animal.
