Figure 1

Manhattan plots of the meta-analysis of OncoArray and iCOGS datasets for the association of common germline variants and breast cancer-specific survival for patients with metastases at primary breast cancer diagnosis for (A) all breast tumors, (B) ER-positive tumors, and (C) ER-negative tumors. The y axis shows the − log10 P values of each variant analyzed, and the x axis shows their chromosome position. The red horizontal line represents P = 5 × 10−8.