Table 2 Cox models for melanoma-specific survival in relation to changes in Breslow thickness between the initial punch biopsy and final excision specimens.

From: Effect of changes in Breslow thickness between the initial punch biopsy results and final pathology reports in acral lentiginous melanoma patients

 

Univariate

Multivariatea

HR (95% CI)

P-value

HR (95% CI)

P-value

Breslow thickness change

 Decreased or same (group 1)

(Reference)

 

(Reference)

 

 Increased (group 2)

1.30 (0.38–4.22)

0.993

0.55 (0.12–2.53)

0.447

Nodal metastasis

 No

(Reference)

 

(Reference)

 

 Yes

6.66 (2.01–22.08)

0.002

5.66 (1.08–29.76)

0.041

Final Breslow thickness, mm

 ≤ 2

(Reference)

 

(Reference)

 

 > 2

7.62 (1.59–36.55)

0.011

9.93 (1.04–94.96)

0.046

Ulceration

 No

(Reference)

 

(Reference)

 

 Yes

2.76 (0.85–8.92)

0.090

2.83 (0.63–12.71)

0.175

Mitosis, n/mm2

 0–1

(Reference)

 

(Reference)

 

 2 < 

3.07 (0.88–10.64)

0.078

0.85 (0.15–4.91)

0.851

Lymphovascular invasion

 No

(Reference)

 

(Reference)

 

 Yes

2.94 (0.87–9.90)

0.082

4.04 (0.88–18.47)

0.072

  1. CI confidence interval, HR hazard ratio.
  2. Among all covariates in Table 1, variables with P-values less than 0.1 in univariate Cox analysis were listed (except for changes in Breslow thickness) and included (with age and sex) in multivariate analysis.
  3. aMultivariate Cox analysis was performed using age, sex, and all variables in the list.
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