Figure 1

Antibody responses against predicted RBD epitopes in sera from vaccinated monkeys. (A) Antibody response against each predicted B cell epitope in the RBD. (B) Number of sera in the vaccinated group reacting with each peptide based on the criteria set. (C) Patterns of antibody responses in different monkeys. ELISA was performed with the synthetic peptide of each predicted epitope to determine antibody response in eight monkeys vaccinated with plant-produced RBD subunit and five control monkeys. Sera were diluted 1:100. * and ** indicates OD450 values in the control and vaccinated groups that are significantly different with p-value < 0.05 and 0.001, respectively. ns: not statistically significant.