Figure 4

Characterization of the immunodominant epitopes using multiple immunoinformatics tools. In addition to linear B cell epitope prediction with BepiPred-2.0, the entire sequence of the SARS-CoV-2 RBD was predicted for coil structure, accessibility, antigenicity and hydrophilicity using the prediction tools as indicated. (A) Alignment of the sequences obtained from each prediction tool. The immunodominant epitopes are indicated (thick box). (B) Determination of common characteristics of the three immunodominant epitopes.