Figure 7

Schematic representation of the SARS-CoV-2 S protein and locations of linear B cell epitope on the S protein. (A) Schematic location of the B cell epitopes on the S protein. (B) Surface representation of the B cell epitopes on the SARS-CoV-2 S trimer. (C) Location of the B cell epitopes in the SARS-CoV-2 S monomer. (D) Secondary structure of the immunodominant B cell epitopes. Closed conformation of the S protein (PDB 6ZB5) is used for epitope labeling. RBD of each subunit and B cell epitopes are illustrated in different colors. Note that 3-D structure of epitopes CoV2_S-20 and CoV2_S-21 were predicted and computationally modeled.