Table 3 Baseline laboratory findings of patients with P. knowlesi infections.

From: A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi

 

Reference ranges

All patients (N = 420)

Patients with cluster 1 infections (N = 298)

Patients with cluster 2 infections (N = 115)

p value

Haemoglobin (g/dL)

12–17

13.3 [12.0–14.6]

13.2 [12–14.7]

13.5 [13–14.2]

0.201

White blood cell count (× 103/µL)

4–10

6.1 [5.0–7.2]

6.1 [5–7.3]

6.2 [5.2–7.1]

0.978

Platelet count (× 103/µL)

150–400

69 [46–104]

64 [41–97]

81 [55–113]

< 0.001

Thrombocytopenic (%)

< 150 × 103 platelets/µL

375 (93.5)

275 (95.2)

95 (89.6)

0.06

Prothrombin time (s)

9.8–14.8

13.5 [12.2–15.4]

13.7 [12.3–15.7]

13.3 [11.9–14.7]

0.042

Serum creatinine (µmol/L)

63–133

92 [80–107]

92 [80–109]

92 [80–106]

0.897

Serum urea (mmol/L)

1.7–8.3

4.9 [3.9–6.4]

5.0 [4.0–7.1]

4.6 [3.5–5.4]

0.002

Serum total bilirubin (µmol/L)

< 17

20.6 [15.–30.0]

21.4 [15.4–31.2]

19.2 [14.2–25.1]

0.049

Serum alanine aminotransferase (IU/L)

< 41

38 [24–61]

38 [24–60]

37 [23–66]

0.790

Serum albumin (g/dL)

35–60

39 [37–41]

39 [36–41]

40 [38-41]

0.071

Serum sodium (mmol/L)

136–152

133 [130–135]

133 [130–135]

133 [131–136]

0.031

Serum glucose (mmol/L)

3.1–6.4 (fasting)

6.4 [5.7–7.5]

6.4 [5.75–7.6]

6.2 [5.5–7.3]

0.191

Plasma lactate (mmol/L)

< 2.5

1.1 [0.8–1.5]

1.1 [0.8–1.5]

1.1 [0.8–1.7]

0.345

Parasite count (parasites/µL)

 

1439 [279–6223]

1250 [255–6100]

1797 [346–5727]

0.832

Parasite count > 20,000 (parasites/µL)

 

49 (11.7)

32 (10.7)

15 (13)

0.494

Parasite count > 100,000 (parasites/µL)

 

17 (4)

12 (4)

4 (3.5)

1.000

Geometric mean of parasite count (parasites/µL)

 

1450 (± 9)

1420 (± 7)

1455 (± 9)

0.922

  1. Data are presented as no. (%), mean (± SD) or median [IQR]. p value < 0.05 are in bold. p value is between cluster 1 and cluster 2.
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