Table 5 Overall distribution of severe criteria among patients infected with P. knowlesi.

From: A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi

Severe criteria

All patients (N = 420)

Patients with cluster 1 infections (N = 298)

Patients with cluster 2 infections (N = 115 )

p value

ARDS

14 (3.3)

10 (3.4)

3 (2.6)

1.000

Hyperparasitaemia

17 (4.0)

12 (4.0)

4 (3.5)

1.000

Hypotension

6 (1.4)

5 (1.7)

1 (0.9)

1.000

Acute kidney injury

20 (5.0)

16 (5.6)

3 (2.8)

0.300

Jaundice

18 (4.3)

13 (4.4)

4 (3.5)

0.789

Acidosis

12 (3.5)

10 (4.1)

2 (2.1)

0.521

Severe anaemia

8 (1.9)

5 (1.7)

3 (2.6)

0.691

Abnormal bleeding

1 (0.2)

1 (0.3)

0

1.000

  1. Data are presented as no. (%). Hyperparasitaemia is defined as > 100,000 parasites/μL; severe anaemia defined as haemoglobin level < 7 g/dL; hypotension—systolic blood pressure < 80 mmHg; acute kidney injury—serum creatinine > 265 μmol/l or blood urea > 20 mmol/l; jaundice—serum bilirubin > 50 μmol/l with parasite count > 20,000/μl; hypoglycaemia—serum glucose < 2.2 mmol/l; acidosis—base deficit > 8 meq/l or plasma bicarbonate < 15 mmol/l or venous plasma lactate ≥ 5 mmol/l; ARDS (acute respiratory distress syndrome)—respiratory rate > 30 breaths/minute plus oxygen saturation < 92% on air and/or pulmonary infiltrates on chest radiograph. p value is between cluster 1 and cluster 2. Abnormal bleeding involved splenic bleeding.
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