Table 2 Varying DNA methylation target CpG site and related genes.

From: Study on the relationship between DNA methylation of target CpG sites in peripheral blood and gestational diabetes during early pregnancy

CpG site a

Gene Symbol

Chr

Distance to TSS

Methylation level (Mean ± SD)

difference b

P value

FDR

GDM (80)

Control (80)

chr20: 37274257

ARHGAP40

20

( +) 43,681

0.601 ± 0.046

0.584 ± 0.048

0.017

0.015

0.033

chr5: 43487508

C5orf34

5

( +) 27,765

0.456 ± 0.078

0.414 ± 0.105

0.042

0.012

0.044

chr7: 157130156

DNAJB6

7

( +) 446

0.010 ± 0.006

0.012 ± 0.005

0.002

0.013

0.033

chr7: 157130085

DNAJB6

7

( +) 375

0.006 ± 0.003

0.007 ± 0.004

0.001

0.018

0.031

chr11: 101980999

YAP1

11

( −) 192

0.009 ± 0.003

0.007 ± 0.003

0.002

0.001

0.013

chr11: 101981060

YAP1

11

( −) 131

0.011 ± 0.004

0.012 ± 0.004

0.001

0.028

0.036

chr21: 34775358

IFNGR2

21

( +) 157

0.024 ± 0.038

0.036 ± 0.039

0.012

0.012

0.044

chr22: 42466321

NAGA

22

( +) 525

0.049 ± 0.014

0.055 ± 0.016

0.006

0.008

0.052

chr14: 68167324

RDH12

14

( −) 1278

0.273 ± 0.009

0.270 ± 0.009

0.003

0.019

0.027

chr14: 68167386

RDH12

14

( −) 1216

0.314 ± 0.009

0.311 ± 0.013

0.003

0.042

0.045

chr15: 89438648

HAPLN3

15

( +) 209

0.011 ± 0.004

0.013 ± 0.006

0.002

0.048

0.048

chr14: 24837915

NFATC4

14

( −) 288

0.015 ± 0.003

0.014 ± 0.003

0.001

0.018

0.031

chr2: 191879104

STAT1

2

( −) 128

0.008 ± 0.003

0.009 ± 0.005

0.001

0.037

0.043

  1. Abbreviation: Chr chromosome, TSS transcription start site and strand; CpG site a: position on chromosome; difference b: the difference of the mean methylation level in the GDM group to that in the Control group.
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