Table 3 Logistic analysis for RA patients with severe sarcopenia.

From: Serum vitamin D status inversely associates with a prevalence of severe sarcopenia among female patients with rheumatoid arthritis

Variables

Univariate

Multivariate

Model 1

Model 2

Model 3

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Age (1 year)

1.15 (1.08–1.22)

 < 0.0001

1.17 (1.09–1.25)

 < 0.0001

1.21 (1.10–1.33)

 < 0.0001

1.21 (1.10–1.33)

 < 0.0001

Body mass index (1 kg/m2)

0.76 (0.67–0.86)

 < 0.0001

0.72 (0.62–0.84)

 < 0.0001

0.76 (0.60–0.95)

0.0085

0.76 (0.60–0.95)

0.010

Low 25(OH)D status (≦16.0 ng/ml)

4.25 (1.99–9.09)

 < 0.0001

4.42 (1.80–10.8)

0.0007

5.92 (1.98–17.7)

0.0006

6.00 (1.99–18.08)

0.0006

DAS28-ESR

1.58 (1.09–2.31)

0.015

  

1.03 (0.62–1.74)

0.90

1.23 (0.86–1.76)

0.88

Stage (3, 4 vs. 1, 2)

4.44 (1.74–11.4)

0.0005

  

4.33 (1.33–14.08)

0.0010

4.40 (1.35–14.32)

0.0097

HAQ

4.03 (2.19–7.41)

 < 0.0001

      

Methotrexate use

0.58 (0.28–1.19)

0.14

  

2.18 (0.66–7.22)

0.19

2.18 (0.66–7.22)

0.19

Prednisolone use

2.91 (1.39–6.11)

0.0049

  

2.45 (0.74–8.06)

0.09

2.45 (0.74–8.06)

0.13

Biological agents use

0.47 (0.21–1.03)

0.058

  

0.70 (0.22–2.21)

0.52

0.70 (0.22–2.21)

0.54

MNA-SF

0.70 (0.59–0.85)

 < 0.0001

  

0.91 (0.66–1.24)

0.54

0.90 (0.66–1.24)

0.53

Osteoporosis medication (+)

1.72 (0.82–3.59)

0.15

    

1.22 (0.40–3.72)

0.73

  1. Results of univariate (left) and multivariate (right) logistic analyses for independent variables associated with severe sarcopenia. Model 1 was adjusted for vitamin D status, age, and body mass index. Model 2 was adjusted for variables in model 1 plus nutrition status (MNA-SF), and RA-related factors (DAS28-ESR, Stage, HAQ, and therapeutics (use of prednisolone, biologics, and methotrexate)). Model 3 was adjusted for variables in model 2 plus the prevalence of osteoporosis medication.
  2. RA rheumatoid arthritis, DAS28 disease activity score using 28 joints, HAQ health assessment questionnaire, MNA-SF Mini Nutritional Assessment Short-Form.
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