Figure 4 | Scientific Reports

Figure 4

From: Treatment of adult metachromatic leukodystrophy model mice using intrathecal administration of type 9 AAV vector encoding arylsulfatase A

Figure 4

Correction of sulfatide storage in the brain and spinal cord. (a) Alcian blue staining of sulfatide in the brain and the spinal cord of 15-month-old MLD mice left untreated or treated with AAV9/ARSA at 1 year or 6 weeks of age. Bar: 200 μM. (b) Sulfatide content detected using thin layer chromatography. Ratios of sulfatide (Sulf) to galactosylceramide (GalC) content (Sulf/GalC ratio) in the brain and cervical spinal cord of MLD mice left untreated (closed bars, n = 5), MLD mice treated at 1 year (gray bars, n = 5) or 6 weeks of age (open bars, n = 4), and wild-type (WT) mice (diagonally hatched bars, n = 8). * P < 0.05, **p < 0.01, ***p < 0.0001.

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