Figure 4 | Scientific Reports

Figure 4

From: Ca2+ imbalance caused by ERdj5 deletion affects mitochondrial fragmentation

Figure 4

Dysfunction of the ER-resident reductase ERdj5 caused aberrant mitochondrial fragmentation due to the imbalance of intracellular Ca2+ homeostasis. The dysfunction of ERdj5 prevents Ca2+ uptake from SERCA2b and causes an imbalance in [Ca2+]i. Increased [Ca2+]i constitutively activates Drp1, which is involved in mitochondrial fission. The calcium imbalance and abnormal mitochondrial fission caused by ERdj5 dysfunction may be responsible for intracellular proteotoxicity.

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