Table 2 Sensitivity, specificity, positive and negative predictive values for the high-sensitivity cardiac troponin cut-offs by risk strata.

From: Cardiac troponin I and T for ruling out coronary artery disease in suspected chronic coronary syndrome

cTn cut-off

Total population (n = 696)

Low risk (n = 232)

Intermediate risk (n = 232)

High risk (n = 232)

% (95% CI)

Patients with cTn > cut-off (% of group)

% (95% CI)

Patients with cTn > cut-off (% of group)

% (95% CI)

Patients with cTn > cut-off (% of group)

% (95% CI)

Patients with cTn > cut-off (% of group)

LoD

hs-cTnI

Sensitivity

NA

696 (100)

NA

232 (100)

NA

232 (100)

NA

232 (100)

Specificity

NA

NA

NA

NA

PPV

NA

NA

NA

NA

NPV

NA

NA

NA

NA

hs-cTnT

Sensitivity

76 (72–80)

504 (72)

56 (46–66)

127 (55)

80 (72–87)

178 (77)

85 (78–90)

200 (86)

Specificity

32 (27–38)

46 (38–55)

28 (19–37)

9 (4–19)

PPV

59 (55–63

43 (34–52)

57 (50–65)

71 (64–77)

NPV

51 (44–59)

60 (50–69)

54 (40–67)

19 (7–36)

Total population median

hs-cTnI

Sensitivity

59 (54–64)

348 (50)

34 (25–45)

60 (26)

64 (55–72)

134 (58)

70 (63–77)

154 (66)

Specificity

62 (56–67)

79 (72–86)

50 (40–60)

44 (31–57)

PPV

66 (61–71)

53 (40–66)

60 (52–69)

77 (69–83)

NPV

54 (49–59)

63 (55–70)

53 (43–63)

36 (25–48)

hs-cTnT

Sensitivity

58 (53–63)

350 (50)

34 (25–45)

62 (27)

61 (52–70)

130 (56)

68 (60–75)

158 (68)

Specificity

59 (53–65)

79 (71–85)

51 (41–60)

31 (20–44)

PPV

64 (59–69)

53 (40–66)

60 (51–69)

72 (65–79)

NPV

52 (47–57)

63 (55–70)

52 (42–62)

27 (17–39)

URL

hs-cTnI

Sensitivity

17 (13–21)

91 (13)

8 (4–16)

12 (5)

17 (11–24)

32 (14)

23 (17–30)

47 (20)

Specificity

92 (88–95)

96 (92–99)

90 (82–95)

86 (75–93)

PPV

73 (42–50)

62 (32–86)

66 (47–81)

81 (67–91)

NPV

46 (42–50)

60 (53–66)

47 (40–54)

30 (23–37)

hs-cTnT

Sensitivity

20 (16–25)

112 (16)

8 (4–16)

13 (6)

19 (13–27)

34 (15)

28 (21–35)

65 (28)

Specificity

89 (85–92)

96 (92–99)

91 (83–95)

72 (59–82)

PPV

71 (61–79)

62 (32–86)

71 (53–85)

72 (60–83)

NPV

47 (43–51)

60 (53–66)

48 (41–55)

28 (23–36)

ROC-AUC (hs-cTnI)

65 (60–69)

 

64 (57–71)

 

59 (52–66)

 

57 (49–66)

 

ROC-AUC (hs-cTnT)

60 (56–64)

 

56 (49–64)

 

57 (50–64)

 

51 (43–59)

 
  1. hs-cTnI – high-sensitivity cardiac troponin I, hs-cTnT – high-sensitivity cardiac troponin T, PPV – positive predictive value, NPV – negative predictive value, ROC-AUC – area under the receiver operating characteristics curve.
Back to article page