Figure 2
Quantitative proteomics and gene expression of ACE2. (a) Principal component analysis (PCA) of the D = Donor and HF = Heart Failure groups based their proteomic expression files. The first and second components segregate the groups and account for 30.8 and 15.1% of the variability, respectively. (b) Vulcano plot of al included proteins showing that ACE2 was one of the proteins that was overexpressed in the HF group. (c) Abundance ratios from TMT quantification where sample abundances are divided with reference abundance. ACE2 was upregulated 2.6 × with a p value of 0.007 (Two-sided student t test) in the HF group. (d) RT-qPCR relative quantification of the gene expression of ACE2 based on RNA from left ventricular tissue from 14 organ donors and 11 HF patients. There was no difference in ACE2 gene expression between the groups.
