Table 1 Gene sets altered only in pyrazoleamide-treated parasites (We mapped Plasmodium genes, with |FC_gene|≥ twofold, onto 509 gene sets in the Malaria Parasite Metabolic Pathway database¹⁸).

Gene set description	N_genes	% of altered genes
Gene set description	N_genes	+ FOS	−APIC	−HXAN	+ PYZ
Cell cycle regulation	53	1.89	1.89	1.89	11.3
Phosphatase-related proteins	38	2.63	2.63	2.63	15.8
LysoPC-sensitive proteins	37	2.70	0.00	0.00	13.5
Mitochondrion electron flow	37	0.00	0.00	2.70	10.8
Tubulin and microtubules	30	0.00	3.33	0.00	13.3
Fatty acid elongation	23	4.35	4.35	4.35	17.4
Centriole proteins	21	4.76	0.00	0.00	14.3
Mitochondrial copper transport	21	0.00	0.00	4.76	14.3

APIC apicoplast-disrupted parasites¹⁹, + FOS, fosmidomycin-treated parasites¹¹, -HXAN hypoxanthine-limited parasites¹², LysoPC lysophosphatidylcholine,+ PYZ pyrazoleamide-treated parasites.
FC_gene denotes fold change in average expression of a gene due to the perturbation relative to its average expression under normal conditions (see “Materials and methods”).

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