Figure 7
From: CCN2-induced lymphangiogenesis is mediated by the integrin αvβ5–ERK pathway and regulated by DUSP6
Enhanced expression of phospho-ERK and DUSP6 in the CCN2 Matrigel. Expression of phospho-ERK, DUSP6 and ERK in Matrigel plugs detected by immunostaining (left) and quantification of the ratio of the ERK, phospho-ERK or DUSP6-positive area to the Podoplanin-positive area for each gel (right). ERK (A), Phospho-ERK (B) and DUSP6 (C)-positive cells were detected in both the CCN2 gel and control gel. Arrowheads indicate Podoplanin-positive/phospho-ERK-positive cells. Scale bars: 50 µm. Student t test, *p < 0.05, **p < 0.01. ns; not significant.
