Table 3 Constants for the rate of nicotine release in the BC during the 60 min use time matching data of Digard et al.37: m = m0 e−bt.

From: A comprehensive physiologically based pharmacokinetic (PBPK) model for nicotine in humans from using nicotine-containing products with different routes of exposure

Product

m0 (mg/min)

b (1/s)

Loose snus (10.79 mg/mL)

0.0678

0.006

Loose snus (27.09 mg/mL)

0.120

0.004

Pouched snus (10.72 mg/mL)

0.065

0.006

Pouched snus (14.67 mg/mL)

0.0879

0.006

  1. m0 rate of nicotine release at time 0, b rate constant, t time.
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