Figure 6
From: Prognostic implications of N6-methyladenosine RNA regulators in breast cancer
Analysis of the hub gene YTHDF1. (A) Survival analysis of YTHDF1. (B) Copy number variation analysis of m6A regulators. Black indicates the copy-number amplification, and blue indicates the copy-number lost. (C) Difference analysis of YTHDF1 in breast cancer. The blue dots represent paracancer samples, and the red ones represent breast cancer samples. (D) The expression of YTHDF1 in the first two clusters. The blue dots represent low immune samples (cluster 1), and the red ones represent high immune samples (cluster 2) (E) Copy number variation analysis of YTHDF1. (F,G) GSEA enrichment analysis. (F) Gene ontology analysis. (G) Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. (H) A schematic diagram of m6A regulators and the genes downstream of YTHDF1 in breast cancer. (I–K) The binding sites of YTHDF1 and its downstream targets were identified. The binding sites of circYap with PABP and eIF4G were predicted by NPDock. The docking quality of the model was confirmed. (I) YTHDF1 and IFI6 mRNA. (J) YTHDF1 and EZR mRNA. (K) YTHDF1 and SPTBN1 mRNA.
