Table 1 Metabolic and biochemical profiles of participants according to ALT level: the AusDiab study.
Normal ALT | Elevated ALT † | Crude OR (95% CI) | Adj OR (95% CI) ‡ | |
|---|---|---|---|---|
Age (years/OR per 1 year) | 61 (53–69) | 57 (51–63) | 0.97 (0.96–0.97) | 0.96 (0.95–0.96) |
Gender | ||||
Female | 55% (n = 2290) | 57% (n = 338) | 1 (reference) | |
Male | 45% (n = 1860) | 43% (n = 259) | 0.94 (0.79–1.12) | 0.64 (0.53–0.78) |
Smoker (vs non-smoker) | 6% (n = 230) | 5% (n = 26) | 0.77 (0.51–1.17) | |
BMI (kg/m2/OR per 1 kg/m2) | 27 (24–30) | 29 (26–33) | 1.08 (1.06–1.09) | § |
Waist circ (cm/OR per 1 cm) | 93.5 (84–103) | 99.3 (90–111) | 1.03 (1.02–1.04) | 1.02 (1.02–1.03) |
T2 Diabetes (vs no T2DM) | 9% (n = 360) | 17% (n = 104) | 2.22 (1.75–2.82) | 1.89 (1.43–2.49) |
Systolic BP (mmHg/OR per 10 mmHg) | 128 (116–142) | 130 (118–142) | 1.00 (1.00–1.01) | |
Diastolic BP (mmHg/OR per 10 mmHg) | 72 (65–79) | 76 (69–83) | 1.03 (1.02–1.04) | 1.01 (1.01–1.02) |
Triglycerides¶ (mmol/L/OR per 1 mmol/L) | 1.1 (0.8–1.6) | 1.4 (1–1.9) | 2.23 (1.89–2.64) | 1.69 (1.39–2.06) |
LDL (mmol/L/OR per 1 mmol/L) | 3 (2.4–3.6) | 3 (2.4–3.7) | 1.05 (0.95–1.16) | |
HDL (mmol/L/OR per 1 mmol/L) | 1.5 (1.2–1.8) | 1.4 (1.1–1.7) | 0.51 (0.41–0.63) | |
Metabolic syndrome (vs no metabolic syndrome) | 38% (n = 1436) | 53% (n = 297) | 2.03 (1.7–2.45) | § |
Exercise | ||||
Sufficient | 64% (n = 2585) | 58% (n = 336) | 1 (reference) | 1 (reference) |
Insufficient | 25% (n = 1019) | 26% (n = 152) | 1.15 (0.94–1.41) | 0.97 (0.78–1.21) |
Sedentary | 11% (n = 440) | 16% (n = 92) | 1.61 (1.25–1.07) | 1.32 (1.01–1.73) |
