Figure 4
From: Spontaneous and TMS-related EEG changes as new biomarkers to measure anti-epileptic drug effects
TRSP modulated by XEN1101 (experiment 2). Grand averages of the time–frequency representation (TFR averaged over ROI channels) of TRSP oscillations recorded before (pre) and after (post) the intake of XEN1101 are shown on the left panel. The blue boxes correspond to the time and frequency windows when comparisons between pre and post conditions showed significant drug effects. Topographical distribution of drug-related effects on the of delta (p = 0.001, 30–160 ms), theta (p = 0.001, 30–420 ms), alpha (p = 0.03, 210–370 ms) and beta (p = 0.01, 210–320 ms) band power are reported for pre and post drug conditions on the right panel. Significant electrodes within the bilateral 27 electrode ROIs are represented with asterisks in the t-statistic maps.
