Figure 1 | Scientific Reports

Figure 1

From: CD97 is associated with mitogenic pathway activation, metabolic reprogramming, and immune microenvironment changes in glioblastoma

Figure 1The alt text for this image may have been generated using AI.

Single-cell analysis of CD97-expressing glioblastoma cells. Glioblastoma (GBM) cells from 14 IDH-wild type cases were subjected to single-cell analysis. (A) Shown is a t-SNE plot classifying cells from these 14 cases into 19 clusters. (B) Neoplastic versus non-neoplastic cells were identified and highlighted in pink via copy number variation (CNV) analysis, with stromal cells shown in cyan. (C) Neoplastic cells (n = 2530) were clustered into 19 distinct cell populations based off differential gene expression. (D) CD97+ and CD97− cells are highlighted among neoplastic cells from these 19 clusters from 14 GBM patient samples. (E) Percentage of CD97+ cells among the 19 clusters derived from 2,530 tumor cells.

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